Pentamidine blocks hepatotoxic injury in mice
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چکیده
منابع مشابه
Mutation of a Major Keratin Phosphorylation Site Predisposes to Hepatotoxic Injury in Transgenic Mice
Simple epithelia express keratins 8 (K8) and 18 (K18) as their major intermediate filament (IF) proteins. One important physiologic function of K8/18 is to protect hepatocytes from drug-induced liver injury. Although the mechanism of this protection is unknown, marked K8/18 hyperphosphorylation occurs in association with a variety of cell stresses and during mitosis. This increase in keratin ph...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2017
ISSN: 0270-9139
DOI: 10.1002/hep.29244